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Johns Hopkins HealthCare psma-negative (psma−) pc3-flu
Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17" width="250" height="auto" />
Psma Negative (Psma−) Pc3 Flu, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
psma-negative (psma−) pc3-flu - by Bioz Stars, 2026-10
90/100 stars

Images

1) Product Images from "Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions"

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

Journal: ACS Omega

doi: 10.1021/acsomega.4c10142

Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17" title="Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice ..." property="contentUrl" width="100%" height="100%"/>
Figure Legend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17

Techniques Used:

Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P18" title="Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice ..." property="contentUrl" width="100%" height="100%"/>
Figure Legend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P18

Techniques Used:

Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-PSMA-617" title="Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice ..." property="contentUrl" width="100%" height="100%"/>
Figure Legend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-PSMA-617

Techniques Used:

Related Articles

Optical Imaging:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Ex Vivo:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Imaging:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Injection:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Expressing:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Fluorescence:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Immunohistochemistry:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Staining:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Control:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Comparison:

Article Title: Comparison of the Effects of DOTA and NOTA Chelators on 64 Cu-Cudotadipep and 64 Cu-Cunotadipep for Prostate Cancer.
Article Snippet: The human prostate cancer cell lines PC3-PIP (PSMA+) and PC3-flu (PSMA−) were kindly provided by Dr. Martin G. Pomper from Johns Hopkins University.

Article Title: 68Ga-labeled NOTA-chelated PSMA-targeted imaging and therapeutic agents
Article Snippet: Six- to eight-week-old male, Nonobese Diabetic (NOD)/Severe Combined immunodeficient (SCID) mice (Johns Hopkins Immune Compromised Animal Core) were implanted subcutaneously (sc) with PSMA+ PC3 PIP and PSMA− PC3 flu cells (1×106 in 100 μL of HBSS (Corning Cellgro, Manassas, Va.) at the forward right and left flanks, respectively.

Article Title: PSMA-targeted radiopharmaceutical for diagnosing and treating prostate cancer
Article Snippet: PC3 PIP (PSMA+) and PC3 flu (PSMA−), the human prostate cancer cell lines, were provided by Dr. Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD).

Article Title: A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation
Article Snippet: The PSMA positive (PSMA+) PC3-PIP and PSMA negative (PSMA−) PC3-FLU were kindly provided by Prof Martin G. Pomper (Johns Hopkins Medical School, Baltimore, MD, USA) [ ].

Article Title: A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
Article Snippet: For optical imaging studies and ex vivo biodistribution, male NOD-SCID mice (Johns Hopkins University, in-house colony) were implanted subcutaneously with 1 × 10 6 PSMA + PC3 PIP and PSMA − PC3 flu cells in opposite flanks.

Article Title: Silicon phthalocyanines functionalized with axial substituents targeting PSMA: synthesis and preliminary assessment of their potential for PhotoDynamic Therapy of prostate cancer.
Article Snippet: Photodynamic therapy (PDT) is a clinical modality based on the irradiation of different diseases, mostly tumours, with light following the selective uptake of a photosensitiser by the pathological tissue.. In this study, two new silicon(IV)phtalocyanines (SiPcs) functionalized at both axial positions with a PSMA inhibitors are reported as candidate photosensitizers for PDT of prostate cancer, namely compounds SiPc-PQ(PSMAi)2 and SiPc-OSi(PSMAi)2.. These compounds share the same PSMA-binding motif, but differ in the linker that connects the inhibitor moiety to the Si(IV) atom: an alkoxy (Si-O-C) bond for SiPc-PQ(PSMAi)2, and a silyloxy (Si-O-Si) bond for SiPc-OSi(PSMAi)2.

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions
Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).



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Image Search Results


Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17" width="100%" height="100%">

Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P18" width="100%" height="100%">

Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P18

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Biodistribution <xref ref-type= a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-PSMA-617" width="100%" height="100%">

Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-PSMA-617

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Biodistribution studies of 125 I-DCIBzL (18.5 MBq) in mice bearing PSMA+ PC3 PIP and PSMA- PC3 flu tumors show increased uptake in PSMA+ PIP tumors compared to kidneys and PSMA- flu tumors over 3 weeks. The PIP tumor:kidney ratio remained at 2-3:1 during this period. Note that kidney uptake at 1 hr and 24 hrs was too high to be evaluated by γ-counter. Values represent mean ± standard deviation. P <0.05 between PIP tumor and kidney at 2 weeks via t-test, non-significant at other time points.

Journal: Theranostics

Article Title: Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen in a micrometastatic model of prostate cancer

doi: 10.7150/thno.38882

Figure Lengend Snippet: Biodistribution studies of 125 I-DCIBzL (18.5 MBq) in mice bearing PSMA+ PC3 PIP and PSMA- PC3 flu tumors show increased uptake in PSMA+ PIP tumors compared to kidneys and PSMA- flu tumors over 3 weeks. The PIP tumor:kidney ratio remained at 2-3:1 during this period. Note that kidney uptake at 1 hr and 24 hrs was too high to be evaluated by γ-counter. Values represent mean ± standard deviation. P <0.05 between PIP tumor and kidney at 2 weeks via t-test, non-significant at other time points.

Article Snippet: For studies evaluating biodistribution in tumor-bearing mice, NSG mice (Animal Resources core, Johns Hopkins, n=5/group) weighing 20-25 g were injected subcutaneously in the right and left flank areas with 1x10 6 PSMA+ PC3 PIP and 1x10 6 PSMA- PC3 flu cells, respectively.

Techniques: Standard Deviation